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KMID : 0525619980030040313
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1998 Volume.3 No. 4 p.313 ~ p.322
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Development of Transdermal Device using Chitosan Matrices 1 . Release Characteristics by Variation Content of Drug and concentration of Plasticizer
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김성현/Kim SH
장미경/나재운/조종수/정영일/김성호/Jang MK/Nah JW/Cho CS/Jeong YI/Kim SH
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Abstract
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The study of drug delivery system has been advanced for effective and safe therapy of drug. Added to chitosan deacetylated from chitin silver sulfadiazine (AgSD) and glycerine, transdermal device chitosan matrix which sustained and controlled was produced. The amount of drug release and release time were controlled by varying the drug content, of drug of glycerine of chitosan matrix. The apparent constant (K) of release ratewas poportirmal to the content of drug or glycerine of chitosan matrix. The release behavior of drug using was consistent with the Higuchi`s diffusion model. These results indicated that chitosan matrix showed some potential as a drug delivery system for transdermal therapeutic application.
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KEYWORD
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